Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells

@article{Chien2009AntimetastaticPO,
  title={Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells},
  author={Chi-Sheng Chien and Kun-Hung Shen and Jau-Shyang Huang and Shian-Chin Ko and Yuan-Wei Shih},
  journal={Molecular and Cellular Biochemistry},
  year={2009},
  volume={333},
  pages={169-180}
}
Fisetin (3,3′,4′,7-tetrahydroxyflavone), a naturally occurring flavonoid, has been reported to possess some anti-cancer and anti-inflammation capabilities. In this study, fisetin has exhibited inhibitory effects on the adhesion, migration, and invasion ability of a highly metastatic PC-3 cells under non-cytotoxic concentrations. Gelatin zymography assay… CONTINUE READING