• Corpus ID: 19592618

Antimetastatic effect of CpG DNA mediated by type I IFN.

@article{Hafner2001AntimetastaticEO,
  title={Antimetastatic effect of CpG DNA mediated by type I IFN.},
  author={Michael Hafner and Rainer Zawatzky and Christian Hirtreiter and Wim A. Buurman and Bernd Echtenacher and Thomas Hehlgans and Daniela N M{\"a}nnel},
  journal={Cancer research},
  year={2001},
  volume={61 14},
  pages={
          5523-8
        }
}
The mechanisms involved in the antimetastatic effect of CpG-containing DNA were investigated in a mouse model of experimental metastasis. Tumor cell colony formation in lungs or livers of mice after i.v. inoculation with syngeneic fibrosarcoma or thymoma cells was determined. The i.v. injection of plasmid DNA or synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs before tumor cell application strongly inhibited metastasis. Because synthetic CpG-ODN was not directly tumor… 

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References

SHOWING 1-10 OF 74 REFERENCES
Interleukin-12 activates NK cells for IFN-gamma-dependent and NKT cells for IFN-gamma-independent antimetastatic activity.
TLDR
IL-12 treatment failed to inhibit metastasis in beta2-microglobulin-deficient mice which lack alphabetaNKT cells in addition to having impaired NK cell activity, thus, demonstrating the functional importance of IL-12-activated NK and alphabeta NKT cells.
Antimetastatic effect of NK1+ T cells on experimental haematogenous tumour metastases in the liver and lungs of mice
TLDR
The results confirmed the fact that NK1+ int T’cells are more potent antitumour effectors than NK cells against experimental haematogenous tumour metastases.
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.
TLDR
It is demonstrated that CpG motifs contained in ODN as short as 15 bases in length were quite effective at inducing NK cell lytic activity in vitro in both human and murine lymphocytes.
CpG DNA and LPS induce distinct patterns of activation in human monocytes
A specific set of immune functions is switched on in response to DNA containing unmethylated CpG dinucleotides in particular base contexts (‘CpG motifs’). Plasmids, viral vectors and antisense
CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells.
TLDR
The ability of specific CpG motifs to strongly activate certain subsets of human DCs to promote Th1-like immune responses is demonstrated, and the use of C pG DNA-based trials for immunotherapy against cancer, allergy, and infectious diseases is supported.
The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
  • G. Weiner
  • Biology, Medicine
    Journal of leukocyte biology
  • 2000
TLDR
Preclinical studies suggest CpG ODN can also enhance innate immunity against a variety of infections, synergize with monoclonal antibody to enhance antibody‐dependent cellular cytotoxicity, and alter the Th1/Th2 balance as a possible treatment for allergic diseases and asthma.
Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α
TLDR
Results indicate that the stimulation of IFN-γ production by bacterial DNA is mediated by IL-12 and TNF-α and point to macrophages/monocytes as targets of action of this macromolecule.
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.
TLDR
Findings imply an important role of bacterial DNA and CpG-ODN in the instruction of adaptive immune responses and point to the therapeutic potential of C pG- ODN in redirecting curative Th1 responses in Th2-driven disorders.
Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha.
TLDR
The results indicate that the stimulation of IFN-gamma production by bacterial DNA is mediated by IL-12 and TNF-alpha and point to macrophages/monocytes as targets of action of this macromolecule.
Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12
TLDR
It is shown that bDNA induces macrophage IL-12 production which, in turn, stimulates NK cell IFN-γ production, and Macrophage-derived IL- 12 renders NK cells responsive to bDNA permitting an even greater IFn-γ response to b DNA.
...
...