• Corpus ID: 19592618

Antimetastatic effect of CpG DNA mediated by type I IFN.

  title={Antimetastatic effect of CpG DNA mediated by type I IFN.},
  author={Michael Hafner and Rainer Zawatzky and Christian Hirtreiter and Wim A. Buurman and Bernd Echtenacher and Thomas Hehlgans and Daniela N M{\"a}nnel},
  journal={Cancer research},
  volume={61 14},
The mechanisms involved in the antimetastatic effect of CpG-containing DNA were investigated in a mouse model of experimental metastasis. Tumor cell colony formation in lungs or livers of mice after i.v. inoculation with syngeneic fibrosarcoma or thymoma cells was determined. The i.v. injection of plasmid DNA or synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs before tumor cell application strongly inhibited metastasis. Because synthetic CpG-ODN was not directly tumor… 

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