Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition.

@article{Oh2006AntimetastaticAO,
  title={Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition.},
  author={S Oh and O Lee and Claudia P. Schroeder and Yun W. Oh and Shi Ke and Hee-Jae Cha and R K Park and Amir Onn and Roy S. Herbst and Chun Sheng Li and Ho-young Lee},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 11},
  pages={
          2685-95
        }
}
Insulin-like growth factor binding protein-3 (IGFBP-3), a major IGF-binding protein in human serum, regulates the growth of non-small cell lung cancer (NSCLC) cells through IGF-dependent and IGF-independent mechanisms. However, the role of IGFBP-3 in lung cancer metastasis is not well known. In the present study, we showed that noncytotoxic doses of adenoviral or recombinant IGFBP-3 significantly decreased the migration and invasion of H1299 and A549 NSCLC cells. Furthermore, treatment of human… CONTINUE READING
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Type 1 insulin-like growth factor regulates Antimetastatic Activities of IGFBP-3 in NSCLC 2694 Mol Cancer Ther 2006;5(11)

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