Antimetastatic activity of a cyclooxygenase-2 inhibitor

@article{RocheNagle2004AntimetastaticAO,
  title={Antimetastatic activity of a cyclooxygenase-2 inhibitor},
  author={Graham Roche-Nagle and Elizabeth M. Connolly and Molly M. Eng and M. Arumugasamy and Judith H. Harmey},
  journal={British Journal of Cancer},
  year={2004},
  volume={91},
  pages={359 - 365}
}
Cyclooxygenase-2 (COX-2) expression is increased in breast cancer and surgery has been shown to increase the growth of metastatic tumours. We investigated the effect of selective COX-2 inhibition on the growth of metastases in either an experimental metastasis model or following excision of a murine primary breast tumour. 50 000 4T1 mammary carcinoma cells were injected into the mammary fat pad of female BALB/c mice. When the mean TD reached 8±0.4 mm, tumours were excised and the mice were… CONTINUE READING
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