Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer

@article{DuHadaway2016AntimetaboliteTS,
  title={Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer},
  author={J. DuHadaway and G. Prendergast},
  journal={Oncotarget},
  year={2016},
  volume={7},
  pages={7372 - 7380}
}
  • J. DuHadaway, G. Prendergast
  • Published 2016
  • Medicine
  • Oncotarget
  • Maintaining thiol homeostasis is an imperative for cancer cell survival in the nutrient-deprived microenvironment of solid tumors. Despite this metabolic vulnerability, a selective approach has yet to be developed to disrupt thiol homeostasis in solid tumors for therapeutic purposes. In this study, we report the identification of 2-mercaptopropionyl glycine disulfide (TTL-315) as a novel antimetabolite that blocks cell survival in a manner conditional on glucose deprivation. In the presence of… CONTINUE READING
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    References

    SHOWING 1-10 OF 36 REFERENCES
    Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
    • 34
    A bioactive probe of the oxidative pentose phosphate cycle: novel strategy to reverse radioresistance in glucose deprived human colon cancer cells.
    • J. Li, Kathleen M. Ward, +4 authors I. Ayene
    • Biology, Medicine
    • Toxicology in vitro : an international journal published in association with BIBRA
    • 2013
    • 4
    A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase
    • 136
    • PDF
    Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses.
    • 484
    • PDF
    Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro.
    • 16
    Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-resistant Cells to Tiopronin*
    • 27
    • PDF