• Corpus ID: 22813947

Antimanic effect of zotepine.

@article{Harada1986AntimanicEO,
  title={Antimanic effect of zotepine.},
  author={Toshiki Harada and Saburo Otsuki},
  journal={Clinical therapeutics},
  year={1986},
  volume={8 4},
  pages={
          406-14
        }
}

• T. Harada, S. Otsuki
• Published 1986
• Medicine
• Clinical therapeutics

The antimanic effect of zotepine was investigated in 16 patients with manic-depressive psychosis or manic schizoaffective psychosis. Zotepine markedly improved manic symptoms in 75% and afforded at least slight improvement in all patients studied. However, in 50%, zotepine caused conversion from mania to depression. The most frequent side effects were dysarthria in 50%, parkinsonian symptoms in 33%, dry mouth in 28%, and sleepiness in 28%. EEG abnormalities were noted in 22% of patients. The antimanic effect of zotepine was enhanced by lithium carbonate; however, concomitant use of zotepine and lithium possibly increased the incidence of EEG abnormalities. The conversion-to-depression effect of zotepine was not inhibited by lithium. Overall, the concomitant use of zotepine and lithium may be important in the treatment of manic psychoses.