Antimalarial solid self-emulsifying system for oral use: in vitro investigation.

@article{Bhandari2017AntimalarialSS,
  title={Antimalarial solid self-emulsifying system for oral use: in vitro investigation.},
  author={Sameer Bhandari and Vikas Rana and Ashok K Tiwary},
  journal={Therapeutic delivery},
  year={2017},
  volume={8 4},
  pages={201-213}
}
AIM The low aqueous solubility of artemether and lumefantrine makes them less bioavailable. It is expected that by formulating self-microemulsifying drug-delivery systems (SMEDDS), their aqueous solubility and absorption will thus be enhanced. Results & methodology: Optimized liquid SMEDDS containing artemether and lumefantrine was adsorbed on Neusilin US2® employing spray drying technique to convert it into solid SMEDDS. Almost 90% of both drugs were released within 15 min in their respective… CONTINUE READING