Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

@article{Laurent2006AntimalarialPO,
  title={Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.},
  author={D. Laurent and V. Jullian and A. Parenty and M. Knibiehler and D. Dorin and S. Schmitt and O. Lozach and N. Lebouvier and M. Frostin and F. Alby and S. Maurel and C. Doerig and L. Meijer and M. Sauvain},
  journal={Bioorganic \& medicinal chemistry},
  year={2006},
  volume={14 13},
  pages={
          4477-82
        }
}
As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary screening, the ethanolic crude extract of a new species of Xestospongia collected in Vanuatu was selected for its promising activity. A bioassay-guided fractionation led us to isolate xestoquinone which inhibits Pfnek-1 with an IC(50) around 1 microM. Among a small panel of plasmodial protein… Expand
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