Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 2: a clinical phase IIB trial.

@article{Mesia2012AntimalarialEO,
  title={Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 2: a clinical phase IIB trial.},
  author={Kahunu Mesia and Lutete Tona and Ma Miezi Mampunza and Nsengi Y. Ntamabyaliro and Tsobo Muanda and T. J. J. Muyembe and Tshinanu Musuamba and Tony Mets and Kanyanga Cimanga and Jozef Tott{\'e} and Luc Pieters and Arnold J. Vlietinck},
  journal={Planta medica},
  year={2012},
  volume={78 9},
  pages={
          853-60
        }
}
According to the promising results of the Phase I and Phase IIA clinical trials with the herbal medicinal product PR 259 CT1 consisting of an 80 % ethanolic extract of the stem bark of Nauclea pobeguinii containing 5.6 % strictosamide, a Phase IIB study was conducted as a single blind prospective trial in 65 patients with proven Plasmodium falciparum malaria to evaluate the effectiveness and safety of this herbal drug. The study was carried out simultaneously using an artesunate-amodiaquine… CONTINUE READING
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