Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 1: a clinical phase IIA trial.

@article{Mesia2012AntimalarialEO,
  title={Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 1: a clinical phase IIA trial.},
  author={Kahunu Mesia and Lutete Tona and Ma Miezi Mampunza and Nsengi Y. Ntamabyaliro and Tsobo Muanda and Tamfum Muyembe and Kanyanga Cimanga and Jozef Tott{\'e} and Tony Mets and Luc Pieters and Arnold J. Vlietinck},
  journal={Planta medica},
  year={2012},
  volume={78 3},
  pages={211-8}
}
The aim of this phase IIA clinical trial was to assess the efficacy of an 80 % ethanolic quantified extract (containing 5.6 % strictosamide as the putative active constituent) from Nauclea pobeguinii stem bark denoted as PR 259 CT1 in a small group of adult patients diagnosed with uncomplicated falciparum malaria. Results obtained from a phase I clinical trial on healthy male volunteers indicated that the oral administration during meals of two 500 mg capsules three times daily (each eight… CONTINUE READING