Antimalarial drugs inhibit phospholipase A2 activation and induction of interleukin 1beta and tumor necrosis factor alpha in macrophages: implications for their mode of action in rheumatoid arthritis.

@article{Bondeson1998AntimalarialDI,
  title={Antimalarial drugs inhibit phospholipase A2 activation and induction of interleukin 1beta and tumor necrosis factor alpha in macrophages: implications for their mode of action in rheumatoid arthritis.},
  author={J. Bondeson and R. Sundler},
  journal={General pharmacology},
  year={1998},
  volume={30 3},
  pages={
          357-66
        }
}
  • J. Bondeson, R. Sundler
  • Published 1998
  • Biology, Chemistry, Medicine
  • General pharmacology
  • 1. The effects of antimalarial drugs on the intracellular signaling leading to activation of the phospholipase C and phospholipase A2 pathways and the induction of proinflammatory cytokines have been studied in mouse macrophages. 2. Both chloroquine and quinacrine, and to a lesser extent hydroxychloroquine, inhibited arachidonate release and eicosanoid formation induced by phorbol diester. This inhibition was due to that of the activation of the arachidonate-mobilizing phospholipase A2. 3. All… CONTINUE READING
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