Antimalarial drug resistance and combination chemotherapy.

@article{White1999AntimalarialDR,
  title={Antimalarial drug resistance and combination chemotherapy.},
  author={Nicholas J. White},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1999},
  volume={354 1384},
  pages={
          739-49
        }
}
Antimarial drug resistance develops when spontaneously occurring parasite mutants with reduced susceptibility are selected, and are then transmitted. Drugs for which a single point mutation confers a marked reduction in susceptibility are particularly vulnerable. Low clearance and a shallow concentration-effect relationship increase the chance of selection. Use of combinations of antimalarials that do not share the same resistance mechanisms will reduce the chance of selection because the… CONTINUE READING

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