Antimalarial drug discovery: efficacy models for compound screening

@article{Fidock2004AntimalarialDD,
  title={Antimalarial drug discovery: efficacy models for compound screening},
  author={David A. Fidock and Philip J. Rosenthal and Simon L. Croft and Reto Brun and Solomon Nwaka},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={509-520}
}
Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to develop safe and affordable new drugs to counter the spread of malaria parasites that are resistant to existing agents. Drug efficacy, pharmacology and toxicity are important parameters in the selection of compounds for development, yet little attempt has been made to review and standardize antimalarial drug-efficacy screens. Here, we suggest different in vitro and in vivo screens for antimalarial drug… 
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821 Citations

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