Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.

@article{Yang2010AntimalarialBD,
  title={Antimalarial bromotyrosine derivatives from the Australian marine sponge Hyattella sp.},
  author={Xinzhou Yang and Rohan A Davis and Malcolm S Buchanan and Sandra Duffy and Vicky M. Avery and David M. Camp and Ronald J. Quinn},
  journal={Journal of natural products},
  year={2010},
  volume={73 5},
  pages={985-7}
}
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the identification of a new bromotyrosine alkaloid, psammaplysin G (1), along with the previously isolated compound, psammaplysin F (2). When tested against two different strains of the parasite Plasmodium falciparum (Dd2 and 3D7), 2 displayed IC(50) values of 1.4 and 0.87 microM, respectively, while 1 showed 98% inhibition at 40 microM against the chloroquine… CONTINUE READING

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