Antimalarial and Antiproliferative Cassane Diterpenes of Caesalpinia sappan.


Bioassay-guided fractionation of a methanol extract of the seeds of Caesalpinia sappan led to the isolation of 12 new cassane-type diterpenes, caesalsappanins A-L (1-12). Their structures were elucidated on the basis of NMR and HRESIMS analysis, and the absolute configuration of compound 1 was determined by single-crystal X-ray crystallography. All isolated compounds were tested against a chloroquine-resistant Plasmodium falciparum strain for antiplasmodial activities and against a small panel of human cancer cell lines for antiproliferative activities. Compounds 7 and 8 displayed antimalarial activity against the chloroquine-resistant K1 strain of P. falciparum with IC50 values of 0.78 and 0.52 μM and selectivity indices of 17.6 and 16.4, respectively. Compound 10 showed antiproliferative activity against the KB cancer cell line with an IC50 value of 7.4 μM.

DOI: 10.1021/acs.jnatprod.5b00317

Cite this paper

@article{Ma2015AntimalarialAA, title={Antimalarial and Antiproliferative Cassane Diterpenes of Caesalpinia sappan.}, author={Guoxu Ma and Haifeng Wu and Deli Chen and Nai-Liang Zhu and Yin-di Zhu and Zhonghao Sun and Pengfei Li and Junshan Yang and Jingquan Yuan and Xu-Dong Xu}, journal={Journal of natural products}, year={2015}, volume={78 10}, pages={2364-71} }