Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).

@article{Cachet2009AntimalarialAO,
  title={Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).},
  author={Nadja Cachet and Franciane Hoakwie and St{\'e}phane Bertani and Genevi{\`e}ve Bourdy and Eric Deharo and Didier Stien and Emeline Houel and Heinz Gornitzka and Judith Fillaux and S{\'e}verine Chevalley and Alexis Valentin and Val{\'e}rie Jullian},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 10},
  pages={4393-8}
}
We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory… CONTINUE READING
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