Antimalarial activity of molecules interfering with Plasmodium falciparum phospholipid metabolism. Structure-activity relationship analysis.

@article{Calas1997AntimalarialAO,
  title={Antimalarial activity of molecules interfering with Plasmodium falciparum phospholipid metabolism. Structure-activity relationship analysis.},
  author={Mich{\`e}le Calas and Gordon Cordina and Jacques Bompart and M Ben Bari and T Jei and Marie Laure Ancelin and Henri J. Vial},
  journal={Journal of medicinal chemistry},
  year={1997},
  volume={40 22},
  pages={3557-66}
}
A series of 80 compounds, primary, secondary, and tertiary amines and quaternary ammonium and bisammonium salts, most of them synthesized as potential choline or ethanolamine analogs, were tested against the in vitro growth of Plasmodium falciparum, the human malaria parasite. They were active over the 10(-3)-10(-8) M concentration range. A structure-activity relationship study was carried out using autocorrelation vectors as structural descriptors, and multidimensional analysis. Principal… CONTINUE READING
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