Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship.

@article{Kalauni2006AntimalarialAO,
  title={Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship.},
  author={Surya Kant Kalauni and Suresh Awale and Yasuhiro Tezuka and Arjun Hari Banskota and Thein Zaw Linn and Puji Budi Setia Asih and Din Syafruddin and Shigetoshi Kadota},
  journal={Biological & pharmaceutical bulletin},
  year={2006},
  volume={29 5},
  pages={1050-2}
}
Malaria is one of the most life-threatening infectious diseases worldwide and claims millions of people's lives each year. The appearance of drug-resistance Plasmodium falciparum has made the treatment of malaria increasingly problematic, and thus, it is a dire need to search the new alternatives of current drugs. In the present study, 44 cassane- and norcassane-type diterpenes isolated from Caesalpinia crista of Myanmar and Indonesia were evaluated for their antimalarial activity against the… CONTINUE READING
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Inhibitory Effects of Constituents from Caesalpinia crista on Growth of Plasmodium falciparum FCR-3/A2 Clone in Vitro Compounds IC50 (mM) Compounds IC50 (mM

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