Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.

@article{Gmez1990AntimalarialAO,
  title={Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.},
  author={Z M G{\'o}mez and Pradipsinh K Rathod},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 7},
  pages={1371-5}
}
Malarial parasites, in contrast to mammalian cells, utilize orotic acid more efficiently than uracil or uridine. Recently, chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum were shown to be inhibited by 5-fluoroorotate, with a 50% inhibitory concentration of 6 nM in vitro. Mammalian cells were far less sensitive to 5-fluoroorotate, particularly in the presence of uridine. In this report, the antimalarial activity of 5-fluoroorotate was tested in vivo. Initially… CONTINUE READING