• Corpus ID: 55072490

Antimalarial activities of Breynia Nivosa

@article{Jude2015AntimalarialAO,
  title={Antimalarial activities of Breynia Nivosa},
  author={E Jude and Davis Koofreh and Bala Adamu Azare},
  journal={Journal of Herbal Drugs: International Journal on Medicinal Herbs},
  year={2015},
  volume={5},
  pages={168-172}
}
  • E. Jude, D. Koofreh, B. Azare
  • Published 2015
  • Medicine, Biology
  • Journal of Herbal Drugs: International Journal on Medicinal Herbs
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg… 

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References

SHOWING 1-10 OF 19 REFERENCES
Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures
SummaryCell suspension cultures developed from Artemisia annua exhibited antimalarial activity against Plasmodium faldparum in vitro both in the n-hexane extract of the plant cell culture medium and
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.
  • W. Peters
  • Medicine
    Experimental parasitology
  • 1965
The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action.
A series of N-benzyloxydihydrotriazines were prepared and found to have antimalarial activity against Plasmodium berghei infections in mice. One of the most active of these compounds. 4,6-diamino-1...
Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis.
TLDR
It is demonstrated that the side chain of bruceantin is important for transport of the drug into intact cells and that partial unsaturation in ring A is required for inhibition of protein synthesis.
Bioactive Compounds from Natural Sources: Isolation, Characterization and Biological Properties
TLDR
Biological Screening Methods in the Search for Pharmac Active Natural Products and Applications of Modern NMR Techniques in the Structural Elucidation of Bioactive Natural Products.
A new approach to practical acute toxicity testing
  • D. Lorke
  • Medicine
    Archives of Toxicology
  • 2005
TLDR
Using this, it is possible to obtain with 13 experimental animals adequate information on the acute toxicity and on the LD50, and this method has no limitations and applies to drugs, agricultural and industrial chemicals.
In vivo testing in the study of toxicity and safety evaluation
  • In: A guide to general toxicology. Marquis J. K . (Ed). 2nd Edn Karger, New York
  • 1989
Drug Resistance in Plasmodium berghei
  • Experimental Parasitology., 17, 80-89.
  • 1965
...
...