Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.

@article{White2016AntimalarialAO,
  title={Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.},
  author={Nicholas J White and Tran Thanh Duong and Chirapong Uthaisin and François H Nosten and Aung Pyae Phyo and Borimas Hanboonkunupakarn and Sasithon Pukrittayakamee and Podjanee Jittamala and Kittiphum Chuthasmit and Ming Sin Cheung and Yiyan Feng and Ruobing Li and Baldur P Magnusson and Marc Sultan and Daniela Wieser and Xiaolei Xun and Rong Zhao and Thierry Tidiane Diagana and Peter E Pertel and Florence W. Leong},
  journal={The New England journal of medicine},
  year={2016},
  volume={375 12},
  pages={1152-60}
}
BACKGROUND KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. METHODS We conducted a phase 2, open-label, two-part study at five centers in Thailand and Vietnam to assess the antimalarial efficacy, safety, and pharmacokinetic profile of KAF156 in adults with acute Plasmodium vivax or P. falciparum malaria. Assessment of parasite clearance rates in cohorts… CONTINUE READING
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