Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi

@inproceedings{Farokhi2013AntimalarialAO,
  title={Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi},
  author={Fereshteh Farokhi and Philippe Grellier and Monique Cl{\'e}ment and Christos Roussakis and Philippe Marie Loiseau and Emilie Genin-Seward and Jean-Michel Kornprobst and Gilles Barnathan and Ga{\"e}tane Wielgosz-Collin},
  booktitle={Marine drugs},
  year={2013}
}
The marine sponge, Axinyssa djiferi, collected on mangrove tree roots in Senegal, was investigated for glycolipids. A mixture containing new glycosphingolipids, named axidjiferoside-A, -B and -C, accounted for 0.07% of sponge biomass (dry weight) and for 2.16% of total lipids. It showed a significant antimalarial activity, with a 50% inhibitory concentration (IC50) of 0.53 ± 0.2 μM against a chloroquine-resistant strain of Plasmodium falciparum. They were identified as homologous… CONTINUE READING
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