Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.

  title={Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.},
  author={Ilias Muhammad and D. Chuck Dunbar and Satoshi Takamatsu and Larry A. Walker and Alice Mae Clark},
  journal={Journal of natural products},
  volume={64 5},
Bioassay-guided isolation of Duguetia hadrantha yielded two new 4,5-dioxo-1-azaaporphinoids, hadranthine A (1) and hadranthine B (2), together with the known alkaloids imbiline-1 (3), sampangine (4), and 3-methoxysampangine (5), whose structures were determined primarily from 2D-NMR 1H-13C HMBC, and 1H-15N HMBC experiments. This is the first report of the co-occurrence of the copyrine alkaloids 4 and 5, as well as the first report of either copyrine or imbiline type alkaloids from a Duguetia… 

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