Antilipolytic effects of sulfonylurea drugs on induced lipolysis in isolated fat cells of the rat.

@article{Brown1967AntilipolyticEO,
  title={Antilipolytic effects of sulfonylurea drugs on induced lipolysis in isolated fat cells of the rat.},
  author={J. D. Brown and D. B. Stone},
  journal={Endocrinology},
  year={1967},
  volume={81 1},
  pages={
          71-6
        }
}
The effect of tolbutamide and tolazamide on fatty acid and glycerol release in vitro was examined in fat cells isolated from epididymal adipose tissue of fasted rats. Incubations were performed in the absence of glucose. Tolbutamide reduced basal rate of release of both glycerol and fatty acid. Both tolbutamide and tolazamide blocked the lipolytic effect of DLarterenol, ACTH, theophylline and glucagon. Tolbutamide inhibited the lipolytic effect of dexamethasone and growth hormone whether it was… 
IN VITRO EFFECTS OF PHENFORMIN HYDROCHLORIDE: OBSERVATIONS USING ISOLATED FAT CELLS *
TLDR
The results indicate that phenformin has in uitro antilipolytic effects in isolated fat cells of the rat.
Mechanism of action of antilipolytic agents: comparison of the effects of insulin, tolbutamide, and phenformin on lipolysis induced by dibutyryl cyclic AMP plus theophylline.
TLDR
The effect of insulin, tolbutamide and phenformin on lipolysis in vitro was examined in isolated fat cells from epididymal adipose tissue of fasted rats to find both small and large concentrations of dibutyryl cyclic AMP plus theophylline inhibited Lipolysis.
Effect of sodium salicylate on induced lipolysis in isolated fat cells of the rat.
TLDR
It is suggested that sodium salicylate is a non-specific inhibitor of lipolysis in the adipose tissue cell and may inhibit the activation of triglyceride lipase by cyclic AMP or may directly inhibit the triglyceridelipase enzyme system.
Antilipolytic Action of Tolbutamide in Isolated Fat Cells of the Rat
Concentrations of tolbutamide from 0.25 to 4.0 mg. per milliliter were found to inhibit epinephrine-stimulated lipolysis in isolated fat cells of the rat. At a concentration of 1 mg. per milliliter,
Effects of sulfonylureas (tolbutamide, glipentide and glibenclamide) on in vitro glycerol metabolism in adipose tissue from rats.
TLDR
The data support the possibility that sulfonylureas might act as uncoupling agents in adipose tissue and the effects of tolbutamide, glipentide and glibenclamide on the utilization of glycerol in adiposes tissue from fed rats was studied.
Chlorpropamide and lipid metabolism of rat and human adipose tissue in vitro.
TLDR
The present findings lend no support to the recent theory that sulfonylureas decrease the plasma levels of FFA and glycerol in man by direct action of the drug on adipose tissue by chlorpropamide.
Metabolic effects of hypoglycemic sulfonylureas. II. In vitro effect of sulfonylureas on cell-free protein synthesis and energy metabolism in rat tissues.
Abstract The hypoglycemic sulfonylureas chlorpropamide, tolbutamide and carbutamide were found to decrease simultaneously and practically to the same extent, cellular levels of ATP and the
Effect of amitriptyline on lipolysis and cyclic AMP concentration in isolated fat cells.
Abstract The effect of amitriptyline on lipolysis and intracellular concentration of cyclic AMP in vitro was examined in fat cells isolated from epididymal adipose tissue of fasted rats. Incubations
Effects of tolbutamide and of chlorpropamide on fatty acid synthesis.
TLDR
Both chlorpropamide and tolbutamide stimulated lipogenesis depressed by fasting, and increased fatty acid synthesis in re-fed animals, and these effects were similar to, and appeared to be of the same degree as, those induced by insulin but were elicited only by large concentrations of the sulfonylureas.
Effect of chlorpropamide and phenformin on rat liver: the effect on plasma membrane-bound enzymes and cyclic AMP content of hepatocytes in vitro.
TLDR
The results suggest that the plasma membrane plays an important role in the mechanism of action of the two hypoglycemic drugs, but do not exclude the presence of intracellular targets.
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