Antileukotrienes in Upper Airway Inflammatory Diseases

  title={Antileukotrienes in Upper Airway Inflammatory Diseases},
  author={C. Cingi and N. Muluk and K. Ipci and E. Şahin},
  journal={Current Allergy and Asthma Reports},
  • C. Cingi, N. Muluk, +1 author E. Şahin
  • Published 2015
  • Medicine
  • Current Allergy and Asthma Reports
  • Leukotrienes (LTs) are a family of inflammatory mediators including LTA4, LTB4, LTC4, LTD4, and LTE4. By competitive binding to the cysteinyl LT1 (CysLT1) receptor, LT receptor antagonist drugs, such as montelukast, zafirlukast, and pranlukast, block the effects of CysLTs, improving the symptoms of some chronic respiratory diseases, particularly bronchial asthma and allergic rhinitis. We reviewed the efficacy of antileukotrienes in upper airway inflammatory diseases. An update on the use of… CONTINUE READING
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