Antileukotrienes in Upper Airway Inflammatory Diseases

@article{Cingi2015AntileukotrienesIU,
  title={Antileukotrienes in Upper Airway Inflammatory Diseases},
  author={C. Cingi and N. Muluk and K. Ipci and E. Şahin},
  journal={Current Allergy and Asthma Reports},
  year={2015},
  volume={15},
  pages={1-11}
}
  • C. Cingi, N. Muluk, +1 author E. Şahin
  • Published 2015
  • Medicine
  • Current Allergy and Asthma Reports
  • Leukotrienes (LTs) are a family of inflammatory mediators including LTA4, LTB4, LTC4, LTD4, and LTE4. By competitive binding to the cysteinyl LT1 (CysLT1) receptor, LT receptor antagonist drugs, such as montelukast, zafirlukast, and pranlukast, block the effects of CysLTs, improving the symptoms of some chronic respiratory diseases, particularly bronchial asthma and allergic rhinitis. We reviewed the efficacy of antileukotrienes in upper airway inflammatory diseases. An update on the use of… CONTINUE READING
    32 Citations
    The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
    • 14
    • PDF
    Effects of montelukast on human nasal mucosa
    • 2
    Evaluating the role of leukotriene-modifying drugs in asthma management: Are their benefits 'losing in translation'?
    • 6
    Subclinical lower airways correlates of chronic allergic and non‐allergic rhinitis
    • 6
    Current and emerging pharmacotherapy for pediatric allergic rhinitis.
    Inhibition of 5-lipoxygenase alleviates graft-versus-host disease
    • 6
    • PDF

    References

    SHOWING 1-10 OF 109 REFERENCES
    Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.
    • 54
    • PDF
    The Role of Leukotrienes in Nasal Allergy
    • I. Haberal, J. Corey
    • Medicine
    • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
    • 2003
    • 60
    The role of leukotrienes in allergic rhinitis: a review.
    • 87
    The role of leukotrienes in allergic rhinitis.
    • M. Peters-Golden, W. Henderson
    • Medicine
    • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
    • 2005
    • 73
    Montelukast in pediatric asthma management
    • 27
    • PDF
    Acute Effects of Antileukotrienes on Sinonasal Polyposis and Sinusitis
    • 111
    Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor
    • 201
    • PDF