Antileukoprotease in psoriatic scales.

  title={Antileukoprotease in psoriatic scales.},
  author={Oliver Wiedow and J A Young and Matthew D. Davison and Enno Christophers},
  journal={The Journal of investigative dermatology},
  volume={101 3},
Antileukoprotease is known to be an antiproteolytic compound of mucous secretions in humans. While searching for peptide-like inhibitors of neutrophil-derived serine proteases in horny layers of human skin, we isolated a potent inhibitor of human leukocyte elastase (EC and cathepsin G (EC from psoriatic scales. This inhibitor showed inhibitory constants for human leukocyte elastase of approximately 0.5-2 x 10(-10) M and for cathepsin G of 2-4 x 10(-9) N. The N-terminal… CONTINUE READING
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