Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

@inproceedings{Etchin2013AntileukemicAO,
  title={Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells},
  author={Julia Etchin and Qingxiang Sun and Alex Kentsis and Alicia Farmer and Zhongwei Zhang and Takaomi Sanda and Marc R Mansour and Carla Barcel{\'o} and Dilara McCauley and Michael G. Kauffman and Sharon Shacham and Amanda L. Christie and Andrew L Kung and Scott J Rodig and Yuh Min Chook and A Thomas Look},
  booktitle={Leukemia},
  year={2013}
}
Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects. Here, we report the structural analysis and antileukemic activity of a new generation of small-molecule inhibitors of CRM1. Designated selective inhibitors of nuclear export (SINE), these compounds were developed using molecular modeling to screen a small… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

Acute Myeloid Leukemia: A Concise Review

Journal of clinical medicine • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Similar Papers

Loading similar papers…