Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).

@article{Niewerth2014AntileukemicAA,
  title={Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).},
  author={Denise Niewerth and Gerrit Jansen and Lesley F V Riethoff and Johan van Meerloo and Andrew J. Kale and Bradley S. Moore and Yehuda G Assaraf and Janet L. Anderl and Sonja Zweegman and Gertjan J. L. Kaspers and Jacqueline Cloos},
  journal={Molecular pharmacology},
  year={2014},
  volume={86 1},
  pages={
          12-9
        }
}
  • Denise Niewerth, Gerrit Jansen, +8 authors Jacqueline Cloos
  • Published in Molecular pharmacology 2014
  • Biology, Medicine
  • Salinosporamide A (NPI-0052, marizomib) is a naturally occurring proteasome inhibitor derived from the marine actinobacterium Salinispora tropica, and represents a promising clinical agent in the treatment of hematologic malignancies. Recently, these actinobacteria were shown to harbor self-resistance properties to salinosporamide A by expressing redundant catalytically active mutants of the 20S proteasome β-subunit, reminiscent of PSMB5 mutations identified in cancer cells with acquired… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 13 CITATIONS

    Immunoproteasome‐selective and non‐selective inhibitors: A promising approach for the treatment of multiple myeloma

    VIEW 2 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Natural compounds for pediatric cancer treatment

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    (Immuno)proteasomes as therapeutic target in acute leukemia

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Positioning of proteasome inhibitors in therapy of solid malignancies

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 45 REFERENCES

    Molecular mechanisms of acquired proteasome inhibitor resistance.

    VIEW 5 EXCERPTS

    2014b) Anti-leukemic activity and mechanisms underlying resistance to the novel immunoproteasome inhibitor PR924

    • D Niewerth, J van Meerloo, +7 authors GJ Kaspers
    • Biochem Pharmacol
    • 2014
    VIEW 12 EXCERPTS
    HIGHLY INFLUENTIAL