Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

@article{Lai2016AntileukemicSS,
  title={Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90},
  author={Kuei-Hung Lai and Yi-Chang Liu and Jui Hsin Su and Mohamed El‐Shazly and Chih-Fung Wu and Ying-Chi Du and Y M Hsu and Juan-Cheng Yang and Ming-kai Weng and Chia-Hua Chou and Guan-Yu Chen and Yu-Cheng Chen and Mei-Chin Lu},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Two new scalarane sesterterpenoids, 12β-(3′β-hydroxybutanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (1) and 12β-(3′β-hydroxypentanoyloxy)-20,24-dimethyl-24-oxo-scalara-16-en-25-al (2), along with one known tetraprenyltoluquinol-related metabolite (3), were isolated from the sponge Carteriospongia sp. In leukemia Molt 4 cells, 1 at 0.0625 μg/mL (125 nM) triggered mitochondrial membrane potential (MMP) disruption and apoptosis showing more potent effect than 2 and 3. The isolates inhibited… 
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Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis.
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Six new asperane-type sesterterpenoids, asperunguisins A-F (1-6), were isolated from the endolichenic fungus Aspergillus unguis and showed cytotoxicity against the human cancer cell line A549, revealing that the observed cell death was a result of G0/G1 cell cycle arrest via DNA damage followed by cellular apoptosis.
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The potential use of sponge genus Phyllospongia and its metabolites as a pharmaceutical aid in the treatment of inflammation-related diseases including IBD is suggested.
Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.
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This paper reviewed 498 new sesterterpenoids, including their structures, source organisms, country of origin, relevant bioactivities, and biosynthesis, from July 2012 to December 2019.
A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus Penicillium citrinum
TLDR
One isolate, the fungus Penicillium citrinum strain WK-P9, showed activity against Bacillus subtilis JH642 when cultivated in malt extract medium, and one new and three known citrinin derivatives were isolated from the extract of this fungus.
Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology †
TLDR
Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.
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