Antileishmanial activity of lapachol analogues.

  title={Antileishmanial activity of lapachol analogues.},
  author={Nadja Maria Fernandes Lima and Clariane S Correia and Leonor Laura Pinto Leon and G{\'e}rzia M. C. Machado and Maria de F{\'a}tima Madeira and Ant{\^o}nio Euz{\'e}bio Goulart Santana and Mar{\'i}lia Oliveira Fonseca Goulart},
  journal={Memorias do Instituto Oswaldo Cruz},
  volume={99 7},
The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis: L. amazonensis and L. braziliensis. All compounds presented significant activity, being isolapachol acetate the most active against promastigotes, with IC50/24h = 1.6 +/- 0.0 microg/ml and 3.4 +/- 0.5… CONTINUE READING
18 Citations
45 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 45 references

In vitro and in vivo leishmanicidal activity of 2-hydroxy-3(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol)

  • MJ Teixeira, YM De Almeida, +6 authors MML Pompeu
  • Phytother Res 15: 44-48.
  • 2001
Highly Influential
3 Excerpts

Electrochemical studies of isolapachol with emphasis on oxygen interaction with its radical anions

  • MOF Goulart, NMF Lima, +5 authors T Ossowsky
  • J Electroanal Chem
  • 2004
1 Excerpt

reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy

  • Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol
  • Arzneim Forsch/Drug Res
  • 2004

Elec - trochemical study of oxygen interaction with lapachol and its radical anions

  • Goulart MOF, A Liwo, P Falkowsky, T Ossowsky
  • Bioelectrochem
  • 2003

Annex 3: Burden of disease in DALYs by cause, sex and mortality stratum in WHO regions, estimates for 2001

  • WHO-World Health Organization
  • The World Health Report. Geneva.
  • 2002

Similar Papers

Loading similar papers…