Antileishmanial activity of imidothiocarbamates and imidoselenocarbamates

  title={Antileishmanial activity of imidothiocarbamates and imidoselenocarbamates},
  author={David Moreno and Daniel Plano and Ylenia Baquedano and Ant{\'o}nio Jim{\'e}nez-Ruiz and Juan Antonio Palop and Carmen Sanmart{\'i}n},
  journal={Parasitology Research},
In the present study, a family of 15 imidothio- and imidoselenocarbamates (1–15) analogs have been synthesized and screened for their in vitro antileishmanial potential against Leishmania infantum promastigotes. The six most active ones (2, 4, 7, 13, 14, and 15) were also tested in an axenic amastigote model. In order to establish their selectivity indexes (SI) the cytotoxic effect of each compound was also assayed against Jurkat and THP-1 cell lines. Compounds 2 and 4, both with a pyridine… CONTINUE READING
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