Antileishmanial activity of harmaline and other tryptamine derivatives

@article{Evans1987AntileishmanialAO,
  title={Antileishmanial activity of harmaline and other tryptamine derivatives},
  author={A. Tudor Evans and Simon L. Croft},
  journal={Phytotherapy Research},
  year={1987},
  volume={1}
}
Tryptamine derivatives harmaline and α‐ethyltryptamine were found to possess a novel antiparasitic action against human pathogen Leishmania mexicana amazonensis both in vitro and in vivo. In vitro, harmaline was the most potent compound tested, with an ED50 of 99μ, whilst α‐ethyltryptamine (ED50 149 μ) had the best therapeutic index (2). In vivo, α‐ethyltryptamine was most effective when given orally (ED50 47 mg/kg), but was also effective when given topically. We suggest that further… 

Natural products and the development of selective antiprotozoal drugs

The potential of natural plant products as a source of antiprotozoal drugs is discussed with respect to biochemical differences between protozoa and hosts with emphasis onalkaloids, terpenes, quinones and miscellaneous compounds.

The in vitro Effects of Tryptamine, Harmine, and Harmaline on Leishmania tarentolae and the Possible Implications for Leishmaniasis

This work investigated the effects on axenic Leishmania tarentolae cell shape, motility, clumping, and viability as well as on the activity of secreted acid phosphatase (SAP) from L. tarentoae, and found that tryptamine and two other indole derivatives, harmine and harmaline, were, in general, activators of SAP activity.

Growth Inhibitory Impact of Peganum harmala L. on Two Breast Cancer Cell Lines

The results revealed that the P. harmala extracts decreased significantly growth rate and cell survival of cancer cell lines, and the extract induced cell death regarding natural cell growth rate.

In vitro and in vivo activities of Peganum harmala extract against Leishmania major

In vivo studies demonstrated a significant post-treatment decrease in the lesion size and parasite count in infected animals, compared to placebo and control groups and high performance liquid chromatography of the crude extract demonstrated the existence of harmaline and harmine as beta-carboline alkaloids.

Alkaloids with antiprotozoal activity.

IDENTIFICATION AND SIMULTANEOUS ANALYSIS OF HARMANE, HARMINE, HARMOL, ISOVITEXIN, AND VITEXIN IN PASSIFLORA INCARNATA EXTRACTS WITH A NOVEL HPLC METHOD

A high performance liquid chromatographic method for the simultaneous analysis of two flavonoids (iso-vitexin and vitexin), and three indole alkaloids (harmane, harmine, and harmol) was developed.

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