Antileishmanial activity of HIV protease inhibitors.

@article{Savoia2005AntileishmanialAO,
  title={Antileishmanial activity of HIV protease inhibitors.},
  author={Dianella Savoia and Tiziano Allice and P. Tovo},
  journal={International journal of antimicrobial agents},
  year={2005},
  volume={26 1},
  pages={92-4}
}
The proteasomes of some protozoa are possible targets for chemotherapy. Leishmaniasis is a major health problem in human immunodeficiency virus (HIV) co-infected subjects. Two HIV protease inhibitors (PI), indinavir and saquinavir, have been shown to block proteasome functions; we therefore investigated their effects on the growth of two Leishmania spp. (Leishmania major and Leishmania infantum). After 24 h of treatment, both drugs exhibited a dose-dependent antileishmanial activity, with 50… CONTINUE READING

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