Antileishmanial action of organometallic complexes of Pt(II) and Rh(I).

@article{MesaValle1996AntileishmanialAO,
  title={Antileishmanial action of organometallic complexes of Pt(II) and Rh(I).},
  author={Concepci{\'o}n Mesa-Valle and V. Moraleda-Lindez and Dan Craciunescu and Antonio Osuna},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={1996},
  volume={91 5},
  pages={
          627-35
        }
}
The three organometallic complexes [(Cis-PtII (DDH) (2,5-Dihidroxibenzensulfonic)2, RhI(CO)2Cl(2-Aminobenzothiazole) and RhI(CO)2Cl(5-Cl-2-Methilbenzothiazole)] used in this study had been previously found to have a high in vitro activity against promastigote and amastigote like forms of Leishmania donovani. Here, the cytotoxic effect of these new organometallic complexes on the J-774 macrophages were studied. Only the RhI(CO)2Cl(2-Aminobenzothiazole) complex induced substantial toxicity in the… 

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References

SHOWING 1-10 OF 52 REFERENCES

Evaluation of the toxicity of Rh(III) and Pt(II) complexes against Trypanosoma cruzi culture forms.

TLDR
The results obtained show that complexes of Rh(III) with the highest antitumoural activity also appear to be more effective against cultured epimastigotes, and complexes [Rh(L)4X2]+X- where L is a derivative of thiazole present high activity against the parasite.

In vitro action of platinum (II) and platinum (IV) complexes on Trypanosoma cruzi and Leishmania donovani.

TLDR
The in vitro activities of 22 neutral Pt(II) complexes, 4 Pt(IV) complex salts, and one Pt( II) complex salt on epimastigote forms of Trypanosoma cruzi and promastigotes of Leishmania donovani were studied and the known antiparasitic activities of the nifurtimox and pentamidine molecules were confirmed.

Anti-Candida activity of four antifungal benzothiazoles.

TLDR
All the compounds tested were highly active on a nystatin-resistant C. albicans mutant, with IC50s of the order of 10(-6) M-10(-5) M, which means better activity than IV.

In vitro action of new organometallic compounds against Trypanosomatidae protozoa.

TLDR
Of the 10 rhodium complexes tested three proved 100% efficient in inhibiting the growth of the epimastigote forms of T. cruzi while only one worked against the promastigotes of L. donovani.

In vitro activity of organometallic complexes of Ir, Pt and Rh on Trypanosoma b. gambiense, T. b. rhodesiense and T. b. brucei.

TLDR
A series of organometallic drugs were tested in a photometric in vitro assay for trypanocidal activity against the three subspecies of the Trypanosoma brucei group and the four Pentamidine complexes were the most active compounds and showed activities comparable to that of PentAmidine.

Antiparasitic agents. 5. Synthesis and anthelmintic activities of novel 2-heteroaromatic-substituted isothiocyanatobenzoxazoles and benzothiazoles.

TLDR
In mice experimentally infected with Nematospiroides dubius (nematode) and Hymenolepis nana (tapeworm), three derivatives, i.e., 5-isothiocyanato-2-(2-furyl)benzoxazole, show 100% nematocidal activity and two derivatives (5 and 21) show good nematOCidal activity in sheep.

Activity of Antitumor Drugs Against African Trypanosomes

TLDR
Of 49 compounds known to have antitumor properties, 6 were found to have significant activity against Trypanosoma rhodesiense infections in mice, and the percentage of “hits” from these known antitumors was approximately twice as great as when other means are employed for the selection of compounds for this test system.

The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro.

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