Antileishmanial Germacranolides from Calea zacatechichi.

  title={Antileishmanial Germacranolides from Calea zacatechichi.},
  author={Hankui Wu and F. Fronczek and C. Burandt and J. Zjawiony},
  journal={Planta medica},
  volume={77 7},
Phytochemical study of the leaves and stems of Calea zacatechichi Schl. (Asteraceae) led to the isolation of a series of six germacranolides (1-6) with significant antileishmanial activity. The structure of a new compound named by us as calealactone D (1) was determined by NMR and MS, and its absolute configuration by X-ray crystallography. In addition, calealactone E (5) was discovered as a new naturally occurring compound, and the absolute configuration of calealactone C (2) was also… Expand
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