Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene

  title={Antileishmanial Activity of the Estrogen Receptor Modulator Raloxifene},
  author={Juliana Quero Reim{\~a}o and Danilo Ciccone Miguel and Noemi Nosomi Taniwaki and Cristiana T. Trinconi and Jenicer K. U. Yokoyama-Yasunaka and S{\'i}lvia Reni Bortolin Uliana},
  booktitle={PLoS neglected tropical diseases},
BACKGROUND The treatment of leishmaniasis relies mostly on parenteral drugs with potentially serious adverse effects. Additionally, parasite resistance in the treatment of leishmaniasis has been demonstrated for the majority of drugs available, making the search for more effective and less toxic drugs and treatment regimens a priority for the control of leishmaniasis. The aims of this study were to evaluate the antileishmanial activity of raloxifene in vitro and in vivo and to investigate its… CONTINUE READING


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R Lainson, JJ Shaw
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