Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium

  title={Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium},
  author={T. S. Tiuman and T. Ueda-Nakamura and D. A. Garcia Cortez and B. P. Dias Filho and J. Morgado-D{\'i}az and W. de Souza and C. V. Nakamura},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={176 - 182}
  • T. S. Tiuman, T. Ueda-Nakamura, +4 authors C. V. Nakamura
  • Published 2005
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium. This isolated compound was identified through spectral analyses by UV, infrared, 1H and 13C nuclear magnetic resonance imaging, DEPT (distortionless enhancement by polarization transfer), COSY (correlated spectroscopy), HMQC (heteronuclear multiple-quantum coherence), and electron… CONTINUE READING


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