Antileishmanial Activity and Structure-Activity Relationship of Triazolic Compounds Derived from the Neolignans Grandisin, Veraguensin, and Machilin G

@article{Costa2016AntileishmanialAA,
  title={Antileishmanial Activity and Structure-Activity Relationship of Triazolic Compounds Derived from the Neolignans Grandisin, Veraguensin, and Machilin G},
  author={Eduarda C. Costa and Tatiana B. Cassamale and Diego B. Carvalho and Lauriane S. S. Bosquiroli and Mariah Ojeda and Thalita Vieira Nascimento Ximenes and M F C Matos and M{\^o}nica Cristina Toffoli Kadri and Adriano C. M. Baroni and Carla Cardozo Pinto Arruda},
  journal={Molecules},
  year={2016},
  volume={21}
}
Sixteen 1,4-diaryl-1,2,3-triazole compounds 4–19 derived from the tetrahydrofuran neolignans veraguensin 1, grandisin 2, and machilin G 3 were tested against Leishmania (Leishmania) amazonensis intracellular amastigotes. Triazole compounds 4–19 were synthetized via Click Chemistry strategy by 1,3-dipolar cycloaddition between terminal acetylenes and aryl azides containing methoxy and methylenedioxy groups as substituents. Our results suggest that most derivatives were active against… 

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