Antikaliuretic action of trimethoprim is minimized by raising urine pH.

@article{Schreiber1996AntikaliureticAO,
  title={Antikaliuretic action of trimethoprim is minimized by raising urine pH.},
  author={Martin Schreiber and Lynn E. Schlanger and Chi-hong B. Chen and Mahbob Lessan-Pezeshki and Mitchell L. Halperin and A Patnaik and Brian N. Ling and Thomas R. Kleyman},
  journal={Kidney international},
  year={1996},
  volume={49 1},
  pages={
          82-7
        }
}
This study was designed to test the hypothesis that the antikaliuresis caused by trimethoprim could be diminished by alkalinizing the luminal fluid in the CCD, thereby converting trimethoprim from its cationic, active form to an electroneutral, inactive, form. Trimethoprim-induced inhibition of transepithelial Na+ transport was examined in A6 distal nephron cells by analysis of short circuit current. The voltage-dependence of the trimethoprim-induced block of Na+ channels was examined with… 
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