Antiischemic effect of monophosphoryl lipid A in conscious rabbits with hypercholesterolemia and atherosclerosis.

@article{Szilvssy1998AntiischemicEO,
  title={Antiischemic effect of monophosphoryl lipid A in conscious rabbits with hypercholesterolemia and atherosclerosis.},
  author={Zolt{\'a}n Szilv{\'a}ssy and P{\'e}ter Ferdinandy and Christopher W Cluff and Gary T. Elliott},
  journal={Journal of cardiovascular pharmacology},
  year={1998},
  volume={32 2},
  pages={206-12}
}
We studied whether monophosphoryl lipid A (MLA), an endotoxin derivative, protected the heart from planned ischemia in hypercholesterolemic conscious rabbits. Normal and hypercholesterolemic (8-week exposure to 1.5% cholesterol-enriched diet) conscious rabbits with right ventricular electrode and left ventricular polyethylene catheters were subjected to ventricular overdrive pacing (VOP: 500 beats/min over 10 min = control VOP). The resulting intracavitary ST-segment elevation, increase in left… CONTINUE READING