Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.

@article{Asada2004AntiinflammatoryRO,
  title={Antiinflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages.},
  author={Kazuhiro Asada and Shigekazu Sasaki and Takafumi Suda and Kingo Chida and Hirotoshi Nakamura},
  journal={American journal of respiratory and critical care medicine},
  year={2004},
  volume={169 2},
  pages={
          195-200
        }
}
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcriptional factor belonging to the nuclear receptor superfamily. PPARgamma, which is predominantly expressed in adipose tissue, plays a major regulatory role in glucose metabolism and adipogenesis. Interestingly, recent studies have demonstrated PPARgamma expression in monocytes/macrophages and its antiinflammatory activities. However, it is unclear whether alveolar macrophages (AMs) express functional… 

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  • R. Reddy
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References

SHOWING 1-10 OF 59 REFERENCES
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
TLDR
It is shown that PPAR-γ is markedly upregulated in activated macrophages and inhibits the expression of the inducible nitric oxide synthase, gelatinase B and scavenger receptor A genes in response to 15d-PGJ2 and synthetic PPar-γ ligands, suggesting that PPARS and locally produced prostaglandin D2 metabolites are involved in the regulation of inflammatory responses.
Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages*
TLDR
It is shown that the PPARα and PPARγ forms are expressed in differentiated human monocyte-derived macrophages, which participate in inflammation control and atherosclerotic plaque formation and demonstrate a novel function of PPAR in human macrophage with likely consequences in inflammation and Atherosclerosis.
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.
  • M. Ricote, J. Huang, C. Glass
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
It is demonstrated that PPARgamma is expressed in macrophage foam cells of human atherosclerotic lesions, in a pattern that is highly correlated with that of oxidation-specific epitopes and raised the possibility that PPargamma ligands may influence the progression of atherosclerosis.
Peroxisome Proliferator–Activated Receptor Activators Inhibit Lipopolysaccharide-Induced Tumor Necrosis Factor-α Expression in Neonatal Rat Cardiac Myocytes
TLDR
The results suggest that both PPARα and PPARγ activators inhibit cardiac expression of TNF-α in part by antagonizing nuclear factor-κB activity and that treatment with PPAR activators may lead to improvement in congestive heart failure.
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
TLDR
Inhibition of cytokine production may help to explain the incremental therapeutic benefit of NSAIDs observed in the treatment of rheumatoid arthritis at plasma drug concentrations substantially higher than are required to inhibit prostaglandin G/H synthase (cyclooxygenase).
Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
TLDR
It is reported that the PPARγ-specific agonists rosiglitazone and GW7845 strongly inhibited the development of atherosclerosis in LDL receptor‐deficient male mice, despite increased expression of the CD36 scavenger receptor in the arterial wall.
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.
  • C. Su, X. Wen, G. Wu
  • Biology
    The Journal of clinical investigation
  • 1999
TLDR
It is reported here that PPAR-gamma ligands dramatically attenuate cytokine gene expression in colon cancer cell lines by inhibiting the activation of nuclear factor-kappaB via an IkappaB-alpha-dependent mechanism, and thiazolidinedione ligands for PPARS markedly reduce colonic inflammation in a mouse model of IBD.
Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene
TLDR
Evidence is provided that PPARγ's ability to repress iNOS transcription requires the ligand-dependent charge clamp that mediates interactions with CBP and SRC-1, which is consistent with a model in which transrepression byPPARγ is achieved by targeting CBP through direct interaction with its N-terminal domain and via S RC-1-like bridge factors.
15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats
TLDR
It is demonstrated that synovial tissue localized expression of PPAR-γ in patients with rheumatoid arthritis (RA) and its ligands, especially 15d-PGJ2, may be useful in the treatment of RA, to suggest that PPar-γ may be an important immunoinflammatory mediator.
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
TLDR
It is demonstrated that PPAR-γ is neither essential for nor substantially affects the development of the macrophage lineage both in vitro and in vivo, and that inhibitory effects on cytokine production and inflammation may be receptor independent.
...
1
2
3
4
5
...