Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid

@article{Killackey2004AntiinflammatoryPO,
  title={Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid},
  author={J. Killackey and B. Killackey and I. Cerskus and R. Philp},
  journal={Inflammation},
  year={2004},
  volume={8},
  pages={157-169}
}
Abstract3-Hydroperoxy-3-methylphthalide (3-HMP), a structural analog of acetylsalicylic acid (ASA), was found to have some antiinflammatory properties which are distinct from those of ASA. 3-HMP inhibits human platelet aggregation and ATP release in response to low concentrations of collagen but is less effective than ASA. 3-HMP inhibits prostaglandin and thromboxane production from exogenous [14C]arachidonic acid by human platelet lysates in vitro and does so at lower concentrations than ASA… Expand
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