Antiinflammatory effects of tetradecylthioacetic acid involve both peroxisome proliferator-activated receptor alpha-dependent and -independent pathways.

@article{Dyry2005AntiinflammatoryEO,
  title={Antiinflammatory effects of tetradecylthioacetic acid involve both peroxisome proliferator-activated receptor alpha-dependent and -independent pathways.},
  author={Endre Dyr\oy and Arne Yndestad and Thor Ueland and Bente Halvorsen and Jan Kristian Dam{\aa}s and P{\aa}l Aukrust and Rolf Kristian Berge},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 7},
  pages={1364-9}
}
OBJECTIVE Tetradecylthioacetic acid (TTA) is a hypolipidemic antioxidant with immunomodulating properties involving activation of peroxisome proliferator-activated receptors (PPARs). Human endothelial cells express PPARs. We hypothesized that TTA could modulate endothelial cell activation at least partly through PPAR-related mechanisms. METHODS AND… CONTINUE READING