Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia

  title={Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia},
  author={Dasja Pajkrt and J. E. Doran and Fred Koster and Peter G. Lerch and Beat Arnet and Tom van der Poll and Julia ten Cate and Sander J. van Deventer},
  journal={The Journal of Experimental Medicine},
  pages={1601 - 1608}
High-density lipoprotein (HDL) has been found to neutralize LPS activity in vitro and in animals in vivo. We sought to determine the effects of reconstituted HDL (rHDL) on LPS responsiveness in humans in a double-blind, randomized, placebo-controlled, cross-over study. rHDL, given as a 4-h infusion at 40 mg/kg starting 3.5 h before endotoxin challenge (4 ng/kg), reduced flu-like symptoms during endotoxemia, but did not influence the febrile response. rHDL potently reduced the endotoxin-induced… CONTINUE READING
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