Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice.

@article{Zhang2011AntiinflammatoryEO,
  title={Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice.},
  author={Bo Zhang and Zhong-yang Liu and Yan-Yan Li and Ying Luo and Man-ling Liu and Hai-ying Dong and Yan-xia Wang and Yiqing Liu and Peng-tao Zhao and Fa-guang Jin and Zhi-chao Li},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2011},
  volume={44 5},
  pages={573-9}
}
Matrine is one of the main active components of Chinese herb Sophora flavescens Ait (Kushen), which has been demonstrated to be effective in suppressing inflammation. The aim of the present study is to investigate the effect of matrine on LPS-induced lung injury. Lung injury was assessed by histological study and wet to dry weight ratios, as well as cell count and protein content in bronchoalveolar lavage fluid. We also detected MPO activity reflecting neutrophil infiltration and MDA activity… CONTINUE READING

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Treatment with matrine improved LPS - induced lung histopathologic changes , alleviated pulmonary edema and lung vascular leak , inhibited MPO and MDA activity , and reduced the production of inflammatory mediators including TNF-α , IL-6 and HMGB1 .
Treatment with matrine improved LPS - induced lung histopathologic changes , alleviated pulmonary edema and lung vascular leak , inhibited MPO and MDA activity , and reduced the production of inflammatory mediators including TNF-α , IL-6 and HMGB1 .
Treatment with matrine improved LPS - induced lung histopathologic changes , alleviated pulmonary edema and lung vascular leak , inhibited MPO and MDA activity , and reduced the production of inflammatory mediators including TNF-α , IL-6 and HMGB1 .
Treatment with matrine improved LPS - induced lung histopathologic changes , alleviated pulmonary edema and lung vascular leak , inhibited MPO and MDA activity , and reduced the production of inflammatory mediators including TNF-α , IL-6 and HMGB1 .
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