Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain

@article{Strauss2008AntiinflammatoryAN,
  title={Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain},
  author={Kenneth I. Strauss},
  journal={Brain, Behavior, and Immunity},
  year={2008},
  volume={22},
  pages={285-298}
}
Overexpression of COX2 appears to be both a marker and an effector of neural damage after a variety of acquired brain injuries, and in natural or pathological aging of the brain. COX2 inhibitors may be neuroprotective in the brain by reducing prostanoid and free radical synthesis, or by directing arachidonic acid down alternate metabolic pathways. The arachidonic acid shunting hypothesis proposes that COX2 inhibitors' neuroprotective effects may be mediated by increased formation of potentially… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…