Corpus ID: 77863113

Antiinflammatory and antiarthritic activities of lupeol and 19a-H lupeol isolated from strobilanthus callosus and strobilanthus ixiocephala roots

@article{Agarwal2003AntiinflammatoryAA,
  title={Antiinflammatory and antiarthritic activities of lupeol and 19a-H lupeol isolated from strobilanthus callosus and strobilanthus ixiocephala roots},
  author={R. B. Agarwal and Vinod D. Rangari},
  journal={Indian Journal of Pharmacology},
  year={2003},
  volume={35},
  pages={384-387}
}
Objective: To study the antiinflammatory and antiarthritic activities of lupeol and 19 α-H- lupeol isolated from the roots of Strobilanthus callosus and Strobilanthus ixiocephala respectively. Methods: The antiinflammatory activity was evaluated using carrageenan induced rat paw oedema model for acute inflammation and cotton pellet granuloma model for chronic inflammation. Antiarthritic activity was carried out using Freund's adjuvant induced arthritis model. Prednisolone was used as a standard… Expand
Anti-inflammatory activity of sappanchalcone isolated from Caesalpinia sappan L. in a collagen-induced arthritis mouse model
TLDR
The results suggest that sappanchalcone could be used as an anti-inflammatory and bone-protective agent during the treatment of rheumatoid arthritis. Expand
ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITIES OF AERIAL PARTS OF NARAVELIA ZEYLENICA (L) DC.
TLDR
The Anti-inflammatory and Anti-arthritic activity of aerial parts of Naravalia zeylanica was evaluated in Freud's adjuvant induced arthritis model in albino rats and both the extracts (200mg/kg) were statistically significant (p<0.01). Expand
Lupeol, a triterpenoid isolated from Calotropis gigantea latex ameliorates the primary and secondary complications of FCA induced adjuvant disease in experimental rats
TLDR
The results of present study indicate the anti-inflammatory and anti-arthritic activity of lupeol present in the C. gigantea latex is indicated. Expand
Phytochemical Analysis and Antimicrobial, Antinociceptive, and Anti-Inflammatory Activities of Two Chemotypes of Pimenta pseudocaryophyllus (Myrtaceae)
TLDR
The crude ethanol extract and fractions from citral chemotype showed antinociceptive and anti-inflammatory effects. Expand
Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark
TLDR
EtEx has antinociceptive effects arising from anti-inflammatory activity; this activity could be due to the presence of lupeol and betulin. Expand
Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent
Aim: The present research work was carried out to isolate and identify the chemical constituent responsible for the antinflammatory activity of Russelia equisetiformis. Method: Isolation was carriedExpand
Anti-arthritic Effects of Bark Extracts of Holoptelea integrifolia (Roxb). Planch in a Chronic Inflammatory Model
TLDR
All the extracts of Holoptelea integrifolia reduced severity FCA induced arthritis extract, with significant effect at 400 mg /Kg. Expand
Antimicrobial marine natural products from the sponge, Axinella infundibuliformis
The antimicrobial activity of the extracts and pure compounds from the sponge Axinella infundibuliformis collected Mombasa, the Kenyan Coast have been reported. The pure compounds were purified andExpand
IN SILICO PROBING OF ANTI-ARTHRITIC POTENTIAL OF TRADITIONALLY FERMENTED AYURVEDIC POLYHERBAL PRODUCT BALARISHTA REVEALS LUPEOL AND DESULPHOSINIGRIN AS EFFICIENT INTERACTING COMPONENTS WITH UREC
Objective: To assess the anti-arthritic properties of Balarishta , an Ayurvedic fermented poly herbal product used to combat the immunological disorder, Rheumatoid Arthritis which is an autoimmuneExpand
Anti-inflammatory effect of Naravelia zeylanica DC via suppression of inflammatory mediators in carrageenan-induced abdominal oedema in zebrafish model
TLDR
The PCR amplification of DNA extracted from adult zebrafish showed that increased concentration of ENZ considerably downregulates the expression of TNF-α and iNOS, the mediators of inflammation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 12 REFERENCES
Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats.
Lupeol, a pentacyclic triterpene was isolated from C. nurvala stem bark and its ester lupeol linoleate was synthesised. These triterpenes were tested for their anti-inflammatory activity in completeExpand
Anti-inflammatory activity of lupeol and lupeol linoleate in rats.
TLDR
The results suggest that the mechanism of action of triterpenes is different from the non-steroidal anti-inflammatory drug, indomethacin. Expand
Effects of antiinflammatory triterpenes isolated from Leptadenia hastata latex on Keratinocyte Proliferation
TLDR
Results prove that the triterpenes play a pivotal role in the topical antiinflammatory effect of this latex. Expand
Inhibition of serine proteases by anti-inflammatory triterpenoids.
TLDR
Lupeol, alpha-amyrin and the palmitic and linoleic acid esters of these compounds are ineffective or very weak as inhibitors of porcine pancreatic elastase and of Lucilia cuprina and Helicoverpa punctigera leucine aminopeptidases. Expand
Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters.
  • C. Winter, C. C. Porter
  • Chemistry, Medicine
  • Journal of the American Pharmaceutical Association. American Pharmaceutical Association
  • 1957
A number of esters of hydrocortisone and related steroids have been examined for activity in the granuloma inhibition (subcutaneous cotton pellet) test, both after local application of the steroidsExpand
CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT.
  • B. Newbould
  • Medicine
  • British journal of pharmacology and chemotherapy
  • 1963
TLDR
Anti-inflammatory activity was readily observed in certain steroids, pyrazolidines, salicylates and sodium aurothiomalate, and the inhibition obtained by daily treatment with the steroid paramethasone disappeared when treatment was withdrawn. Expand
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
  • C. Winter, E. Risley, G. Nuss
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
TLDR
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease. Expand
Isolation of 19 α‐H‐Lupeol from Maclura pomifera
A reinvestigation of the constituents of the Osage orange (Maclura pomifera) yielded, in addition to the previously reported triterpenes (lupeol, butyrospermol, and lupane‐3β,20‐diol), the pigmentsExpand
Total assignment of 13C and 1H spectra of three isomeric triterpenol derivatives by 2D NMR: an investigation of the potential utility of 1H chemical shifts in structural investigations of complex natural products
It is shown that a recently proposed indirect heteronuclear shift-correlated pulse sequence, XCORFE, can be used to unambiguously assign the 13C spectra of three isomeric (C30H50O) triterpenols:Expand
New insights into the mechanism of action of the antiinflammatory triterpene lupeol
  • J Pharm Pharmacol
  • 2001
...
1
2
...