• Chemistry, Medicine
  • Published in Arzneimittel-Forschung 1988

Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin.

@article{Ohmori1988AntiinflammatoryAA,
  title={Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin.},
  author={Kenji Ohmori and Hiro-taka Ishii and Haruhiko Manabe and Hisashi Satoh and Toru Tamura and Hiroshi Kase},
  journal={Arzneimittel-Forschung},
  year={1988},
  volume={38 6},
  pages={
          809-14
        }
}
The antiallergic and antiinflammatory effects of the new protein kinase C and calmodulin inhibitor K-252a (8R, 9S, 11S)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11- epoxy-1H,8H,11H-2,7b,11a-triazadibenzo [a,g]cycl oocta [cde] trinden-1-one) were investigated in animal models, and the following results were obtained: 1. Oral administration of K-252a, ketotifen or oxatomide showed a dose-dependent inhibition on 48 h homologous passive cutaneous anaphylaxis in rats and… CONTINUE READING