Antiinflammatory activity of the antirheumatic herbal drug, gravel root (Eupatorium purpureum): further biological activities and constituents

  title={Antiinflammatory activity of the antirheumatic herbal drug, gravel root (Eupatorium purpureum): further biological activities and constituents},
  author={S. Habtemariam},
  journal={Phytotherapy Research},
Previous reports from this laboratory revealed that cistifolin from the antirheumatic herbal drug, gravel root (rhizome of Eupatorium purpureum), showed activity both in in vitro and in vivo models of inflammation. Data are now presented to show that, in addition to the LFA‐1 and other integrin‐mediated leucocyte adhesions, cistifolin inhibits the Mac‐1 (CD11b/CD18)‐dependent monocyte adhesion to fibrinogen in a concentration‐dependent manner. Further phytochemical analysis of the crude extract… Expand
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