Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor.

@article{Leal2012AntihypertensivePO,
  title={Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor.},
  author={C. M. Leal and S. L. Pereira and A. K{\"u}mmerle and Daniella M. Leal and R. Tesch and C. D. de Sant'Anna and Carlos A M Fraga and E. Barreiro and R. T. Sudo and G. Zapata-sudo},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={55},
  pages={
          49-57
        }
}
Several N-acylhydrazone derivatives synthesized from safrole have been found to promote intense vasodilation and antihypertensive activity. The present work describes the synthesis and antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone (LASSBio-1027), a new analogue of the lead compound 3,4-methylenedioxybenzoyl-2-thienylhydrazone. Thoracic aortas from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were prepared for isometric tension recording… Expand
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